She has worked as a legal researcher for former Justice Kate O'Regan, current Chief Justice Mogoeng Mogoeng and the late former Chief Justice Arthur Chaskalson of the Constitutional Court of South Africa.

She is a fellow of both Brightest Young Minds and the Aspen Institute's African Leadership Initiative. She is also the 2014 recipient of the Inyathelo Youth in Philanthropy Award in addition to being named one of Mail and Guardian's Top 200 Young People to Watch in 2015. Kgomotso holds a diploma in Social Entrepreneurship from the Gordon Institute of Business Science and practiced at Cheadle Thompson Haysom Inc in Johannesburg for 4 years. She has been the head of SpreadLuv for 8 years. Kgomotso holds a Bachelor of Arts degree in Political Science and Law, a Bachelor of Laws degree and a Masters in Law degree (Intellectual Property and Media Laws) all from the University of the Witwatersrand. She is a member of the Charities Aid South Africa Board of Directors and is the chair of its Governance Committee.

Ms Mokoena's areas of interest include labour law as well as constitutional, media and intellectual property laws. Her personal and professional philosophy is that academic research and legal work should impact and improve the lives of the most vulnerable members of society and that all her work should be rooted in its ability to be practically implemented.